SYMPHONYAge
A revolutionary new way of looking at aging. Discover aging insights on 11 different organ systems.
SYMPHONYAge (System Methylation Proxy of Heterogeneous Organ Years) is a new way of looking at aging by examining how different parts of the body age independently and synchronously.
This big-picture approach helps understand aging better by putting all the pieces of the puzzle together.
It’s crucial to note that our body’s systems don’t age in isolation. Many age-related illnesses stem from issues in various biological systems working together. For instance, arthritis is the result of both musculoskeletal wear and inflammation, whereas stroke can happen due to problems in the cardiovascular system, metabolism, inflammation, and brain function.
These interconnected patterns can lead to different aging types, making some people more prone to certain age-related diseases. Understanding these patterns helps in forecasting health outcomes.
Better Insights
SYMPHONYAge is notably different in scope, validation, and associations with various health outcomes by analyzing 11 different organ systems. Other biological clocks fall short in only measuring 9 differeny systems.
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Understanding Biological Aging
When you think of aging, you may think of some common, outward expressions (phenotypes), such as wrinkles, gray hair, health issues, or limited physical mobility.
These visible traits are reflective of complex, biological processes occurring in your body; processes that are interconnected and occurring at molecular levels all the way down to your DNA. The difference in each of our biological "mileage" is the reason why we may look and feel significantly older or younger than others who share the same birth year as us.
SYMPHONYAge developer Dr. Morgan Levine studies the mechanisms of aging, while recognizing that aging processes do not happen at a uniform pace for everyone.
Central to her exploration is the concept of epigenetics — the factors that influence gene activity without changing the DNA sequence.
Dr. Levine focuses on DNA methylation, which is a significant epigenetic change that occurs with aging, along with the development of models/mathematic algorithms called 'clocks' that can be used to predict biological aging.
While she acknowledges that it might be possible to reverse aging at a cellular level, Dr. Levine clarifies that the ultimate goal is not to “cure” aging or death, but to delay disease onset and improve health span.
