Research Publications and Clinical Trials
Pre-print
June 1, 2024
A genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform
Karsten Suhre, Qingwen Chen, Anna Halama, Kevin Mendez, Amber Dahlin, Nisha Stephan, Gaurav Thareja, Hina Sarwath, Harendra Guturu, Varun B. Dwaraka, Serafim Batzoglou, Frank Schmidt, Jessica A. Lasky-Su
In Progress
Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems
Raghav Sehgal, Margarita Meer, Aladdin H. Shadyab, Ramon Casanova, JoAnn E. Manson, Parveen Bhatti, Eileen M. Crimmins, Themistocles L. Assimes, Eric A. Whitsel, Albert T. Higgins-Chen, Morgan Levine
Published
May 9, 2024
Quantifying the stochastic component of epigenetic aging
Huige Tong, Varun B. Dwaraka, Qingwen Chen, Qi Luo, Jessica A. Lasky-Su, Ryan Smith & Andrew E. Teschendorff
Unknown
Unveiling the Epigenetic Impact of Vegan vs. Omnivorous Diets on Aging: Insights from the Twins Nutrition Study (TwiNS)
Varun B. Dwaraka, Lucia Aronica, Natalia Carreras-Gallo, Jennifer L Robinson, Tayler Hennings, Aaron Lin, Logan Turner, Ryan Smith, Tavis L. Mendez, Hannah Went, Emily R. Ebel, Matthew M. Carter, Erica D. Sonnenburg, Justin L. Sonnenburg, Christopher D. Gardner
Unknown
Genomic map of candidate human imprint control regions: the imprintome
Dereje D. Jima, David A. Skaar, Antonio Planchart, Alison Motsinger-Reif, Sebnem E. Cevik, Sarah S. Park, Michael Cowley, Fred Wright, John House, Andy Liu, Randy L. Jirtle, & Cathrine Hoyo
Pre-print
Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states
Lishomwa C. Ndhlovu, Matthew L. Bendall, Varun Dwaraka, Alina PS Pang, Nicholas Dopkins, Natalia Carreras, Ryan Smith, Douglas F. Nixon, Michael J. Corley
Unknown
Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications
Michael M. Safaee, Varun B. Dwaraka, Justin M. Lee, Marissa Fury, Tavis L Mendez, Ryan Smith, Jue Lin, Dana L. Smith, John F. Burke, Justin K. Scheer, Hannah Went, Christopher P. Ames
Pre-print
Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome
Natalia Carreras-Gallo, Varun B. Dwaraka, Dereje D. Jima, David A. Skaar, Tavis L. Mendez, Antonio Planchart, Wanding Zhou, Randy L. Jirtle, Ryan Smith, Cathrine Hoyo
Pre-print
October 23, 2023
OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records
Qingwen Chen, Varun B. Dwaraka, Natàlia Carreras-Gallo, Kevin Mendez, Yulu Chen, Sofina Begum, Priyadarshini Kachroo, Nicole Prince, Hannah Went, Tavis Mendez, Aaron Lin, Logan Turner, Mahdi Moqri, Su H. Chu, Rachel S. Kelly, Scott T. Weiss, Nicholas J.W Rattray, Vadim N. Gladyshev, Elizabeth Karlson, Craig Wheelock, Ewy A. Mathé, Amber Dahlin, Michae J. McGeachie, Ryan Smith, Jessica A. Lasky-Su
Published
February 22, 2023
Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
Edwin Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner, Aaron Lin , Tavis L. Mendez, Hannah Went, Alan Tomusiak, Eric Verdin, Michael Corley, Lishomwa Ndhlovu, Ryan Smith, Varun B. Dwaraka
Published
January 28, 2022
Meeting Report: Aging Research and Drug Discovery
Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegué, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Björn Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano3, Kris Verburgh68 , Eric Verdin2 , Jan Vijg4 , Rudi G.J. Westendorp69 , Alessandra Zonari70 , Daniela Bakula1 , Alex Zhavoronkov53 , Morten Scheibye-Knudsen
Published
May 13, 2022
Global DNA Methylation Status in Relation to Resistance Training with High vs Low Loads to Failure
Casey Sexton, Joshua Godwin, Bradley Ruple, Mason Mcintosh, Shelby Osburn, Blake Hollingsworth, Philip Agostinelli, Andreas Kavazis, Timothy Zeigenfuss, Hector Lopez, Ryan Smith, Kaelin Young, Varun Dwaraka, Christopher Mobley, Adam Sharples, Michael Roberts
Published
May 1, 2022
Effects of different types of resistance exercise failure training on the methylation status of genes that drive skeletal muscle hypertrophy
Mason McIntosh, Casey Sexton, Josh Godwin, Bradley Ruple, Shelby Osburn, Blake Hollingsworth, Philip Agostinelli, Andreas Kavazis, Timothy Ziegenfuss, Hector Lopez, Ryan Smith, Kaelin Young, Varun Dwaraka, Christopher Mobley, Adam Sharples, Michael Roberts
Published
June 3, 2022
Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
Alina P. S. Pang, Albert T. Higgins-Chen, Ioana RaicaIoana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley
Published
March 15, 2023
Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers
Mason C. McIntosh, Casey L. Sexton , Joshua S. Godwin, Bradley A. Ruple, J. Max Michel, Daniel L. Plotkin, Tim N. Ziegenfuss, Hector L. Lopez, Ryan Smith, Varun B. Dwaraka, Adam P. Sharples, Vincent J. Dalbo, C. Brooks Mobley, Christopher G. Vann, Michael D. Roberts
Published
January 9, 2023
Skeletal Muscle DNA Methylation and mRNA Responses to a Bout of Higher versus Lower Load Resistance Exercise in Previously Trained Men
Casey L. Sexton, Joshua S. Godwin, Mason C. McIntosh, Bradley A. Ruple, Shelby C. Osburn, Blake R. Hollingsworth, Nicholas J. Kontos, Philip J. Agostinelli, Andreas N. Kavazis, Tim N. Ziegenfuss, Hector L. Lopez, Ryan Smith, Kaelin C. Young, Varun B. Dwaraka, Andrew D. Frugé, Christopher B. Mobley, Adam P. Sharples, Michael D. Roberts
Published
April 12, 2023
Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment
Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid & Juan R. González
Published
April 18, 2023
The Effects of a Multi-Ingredient Supplement Containing Wasabia Japonica Extract, Theacrine, and Copper (I) Niacin Chelate on Peripheral Blood Mononuclear Cell DNA Methylation, Transcriptomics, and Sirtuin Activity
Michael D. Roberts, Michael B. La Monica, Betsy Raub, Jennifer E. Sandrock, Tim N. Ziegenfuss, Ryan Smith, Varun B. Dwaraka, Hector L. Lopez
Published
September 1, 2022
27. Cellular aging for risk stratification in adult deformity surgery: utilization of seven epigenetic clocks and two telomere length measurements in the analysis of comorbidity burden, frailty, disability and complications in adult deformity surgery
Michael Safaee, Varun Dwaraka, Justin K. Scheer, Marissa Fury, Tavis Mendez, Ryan Smith, Jue Lin, Dana Smith, Christopher P. Ames, MD
Published
May 1, 2023
513. Metabolic and Inflammatory Changes as Biological Mechanisms Underlying the Accelerated Pace of Epigenetic Aging in Bipolar Disorder
Camila Nayane, Lima Alexandre Rubinstein, Apurva Kumar, Rohit Jha, Esther Soyebo, Mohammad Farhan, Varun Dwaraka, Ann Alexis Prestrud, Ryan Smith, Consuelo Walss-Bass, Joao Quevedo, Jair Soares, Gabriel Fries
Published
May 22, 2023
Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
Natàlia Carreras-Gallo, Varun B. Dwaraka, Alejandro Cáceres, Ryan Smith, Tavis L. Mendez, Hannah Went, Juan R Gonzalez
Published
August 31, 2023
A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Qi Luo, Varun B. Dwaraka, Qingwen Chen, Huige Tong, Tianyu Zhu, Kirsten Seale, Joseph M. Raffaele, Shijie C. Zheng, Tavis L. Mendez, Yulu Chen, Natalia Carreras, Sofina Begum, Kevin Mendez, Sarah Voisin, Nir Eynon, Jessica A. Lasky-Su, Ryan Smith & Andrew E. Teschendorff
Published
April 1, 2023
Abstract 3010: Epigenetic age acceleration in older adults with hematologic malignancies
Ashley E. Rosko; Kaitlyn Dvorak; Jennifer Woyach; Varun Dwaraka; Ryan Smith; Ryann Finlayson; Alice Mims; Christin Burd
Published
December 1, 2023
Epigenetic age biomarkers and risk assessment in adult spinal deformity: a novel association of biological age with frailty and disability
Michael M. Safaee, Varun B. Dwaraka, Justin M. Lee, Marissa Fury, Tavis L. Mendez, Ryan Smith, Jue Lin, Dana L. Smith, John F. Burke, Justin K. Scheer, Hannah Went, and Christopher P. Ames
Published
September 27, 2023
Comprehensive evaluation of the Infinium human MethylationEPIC v2 BeadChip
Diljeet Kaur, Sol Moe Lee, David Goldberg, Nathan J. Spix, Toshinori Hinoue, Hong-Tao Li, Varun B. Dwaraka, Ryan Smith, Hui Shen, Gangning Liang, Nicole Renke, Peter W. Laird, Wanding Zhou
In Progress
Alzheimer's and Imprintome
Big Bold Health: The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
Wild Health: Impact of Ketamine on Epigenetic Age (IKEA)
Doterra
Hyperbaric Oxygen Therapy
Semaglutide: Larry Siegel
Dastinib + Quercetin
Trulacta
AC-11
SRW Laboratories
Blushield
Olaplex Phenotypic Skin Clock Study
Nutratarian Diet aand Longevity: 50:50 study