The Epigenetic Panel Precision Care Requires

TruHealth measures 81 epigenetic markers from a single at-home finger prick, organized into 7 clinical categories:

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• Nutrition — Vitamins (A, B5, B6, C, E, Inositol, Choline, Betaine), Amino Acids (Methionine, Cysteine, S-Methylmethionine, Ergothioneine, Glutamine, N-carbamoylvaline, N-acetylthreonine, N-acetylvaline, Glycine, N-acetylcarnosine, Cystathionine, N-acetylhistidine), Antioxidants (Lutein, Carotene Diol, Acetyl-L-Carnitine), and Fats & Cellular Membranes (Omega-3, DHA, EPA, Omega-6, LA, PUFA, MUFA, SFA, Phosphoglycerides, Phosphatidylcholines, Sphingomyelins).

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• Glycemic & Metabolic — Metabolic Markers (HbA1c, Glucose, Palmitoylcarnitine, Leptin, Phenylacetylglutamine, IGF-1, Adiponectin, Cystatin-C, Erythritol, Homocitrulline), Uric Acid Pathway (Uric Acid, Allantoin).

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• Energy & Oxidative — Oxidative Defense (Methionine Sulfone, Allantoin, Dimethyllysine), NAD+ Metabolism (Nicotinamide Riboside), Supplements (Alpha-Ketoglutarate).

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• Lipid & Vascular — Serum Lipids (ApoB, LDL-C, VLDL-C, VLDL Particle Size, ApoA1, HDL-C, HDL Particle Size, Total Triglycerides), Blood Pressure (Vanillactic Acid, Phenylacetylglutamine, ADMA and SDMA).

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• Immune & Inflammation — Immune Markers (White Blood Cell Count, Neutrophil Count, Lymphocyte Count, CRP, Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, CD4/CD8 Ratio), Inflammation Markers (IL-6, Methionine Sulfone, Serum Amyloid A-1 Protein, Glycoprotein Acetyls).

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• Toxins & Exposures — PFAS (PFOS, PFOA), Acrolein (HPMA), Polycyclic Aromatic Hydrocarbons (2-Hydroxyfluorene Sulfate), Glyphosate.

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• Neurocognitive & Stress — Neurocognitive Markers (Quinolinate, VGF), Stress Markers (Vanilmandelic Acid, Kynurenine, DHEA Sulfate).

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Together, these 81 markers reveal a longer-horizon biological signal across nutrition, metabolic flexibility, oxidative balance, inflammation, toxin burden, and cognitive-stress load, surfacing what may be quietly driving symptoms that conventional panels miss.

TruHealth measures functional and nutritional health through DNA methylation analysis — the same epigenetic technology that powers TruAge — applied to surrogate biomarkers across nutrition, metabolic, immune, mitochondrial, and other functional pathways. Rather than relying solely on direct serum concentrations of vitamins, amino acids, and metabolites — which fluctuate hour-to-hour with meals, hydration, and acute stress — TruHealth reads methylation patterns that reflect a sustained biological signal across weeks to months. This gives providers a stable, system-level view of where a patient's biology actually sits, from a single finger prick.

Many of the conditions that providers spend the most time managing — chronic fatigue, brain fog, cardiometabolic risk, autoimmune flares, persistent inflammation — are downstream of upstream nutritional and functional imbalances that standard labs are not designed to surface.

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Conventional micronutrient panels are snapshot measurements: a single number, measured in plasma or serum, highly sensitive to what a patient ate that morning or how hydrated they are. TruHealth's epigenetic methodology, by contrast, reflects a sustained biological signal across weeks to months — making it more clinically meaningful than a one-day blood result.

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Crucially, epigenetic biomarkers are modifiable. Unlike a fixed genetic test, methylation patterns shift in response to diet, supplementation, sleep, exercise, and pharmacologic intervention — making TruHealth a powerful tool for longitudinal monitoring of what's actually working at the cellular level, not just clinical endpoints.

TruHealth is most clinically useful for patients whose symptoms or risk factors aren't fully explained by standard workups, and for providers building personalized nutrition, lifestyle, or longevity protocols.

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• Patients with unexplained fatigue, brain fog, or persistent low mood whose conventional labs keep returning normal

• Patients with borderline metabolic markers (lipids, HbA1c, blood pressure) whose current protocol improves labs but not symptoms

• Patients on active interventions — supplementation, dietary protocols, GLP-1 agonists, peptides — where you want to measure cellular response, not just clinical endpoints

• Patients with chronic inflammation, autoimmune flares, or borderline immune dysfunction without a clear driver

• Patients invested in longevity and preventive medicine who want a quantitative baseline of their functional biology, with the ability to retest every three to six months

• Patients with suspected environmental exposure burden (toxins, pesticides, PFAS) and no objective workup

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Because TruHealth is not a diagnostic test, it is best positioned as an adjunct to clinical evaluation — a longitudinal functional signal to complement, not replace, standard workup.

TruHealth's biomarker panels are built on the same epigenetic methodology that powers TruAge, and are developed and validated in partnership with Harvard University. The underlying CpG signatures have been benchmarked across multiple independent cohorts and published in peer-reviewed literature.

Providers order directly through the TruDiagnostic Provider Portal. Once your account is set up, you can place orders for clinic delivery or patient drop-ship.

Full pricing is available in the Provider Portal once your account is active. To get started, register as a provider at www.trudiagnostic.com/provider-application.