Wondering how to understand or make the most of your, or your patients', OMICm Age results? Our team has compiled the following resources to help patients and providers analyze their results.
OMICm Age is a novel aging algorithm that was trained on the largest data set ever created, by scientists from TruDiagnostic and Harvard University. It is the most predictive age clock to date, and yields novel insights on protein, metabolite, and other clinical biomarkers that are impacting your biological age. Additionally, our OMICm Age report calculates your risk of Death, Cancer, Stroke, COPD, Depression, Congenital Heart Disease, and Type II Diabetes.
▐ OMICm Age Interpretation
In the webinar below, the TruDiagnostic team dives into the epigenetic findings from an OMICm Age case study participant; highlighting key applications and takeaways from their OMICm Age Report.
Read Along Here
Additional Resources:
- Watch our OMICm Age introduction webinar here.
- Watch a 20 minute, express introduction to OMICm Age here and/or read along here.
- View an OMICm Age report with annotated, explanatory notes here.
▐ EBP Health Associations for OMICm Age
Additional Resources:
- Learn more about the 36 Epigenetic Biomarker Proxies that we report on here.
- Read the newly released pre-print of our OMICm Age study here.
▐ Fast OMICm Age FAQs
What is OMICm Age?
OMICm Age is the newest epigenetic biological age clock created by researchers at TruDiagnostic and Harvard University. It uses some of the most comprehensive aging data ever collected in a single cohort to predict the age of your body through advanced epigenetic methylation algorithms.
Why is OMICm Age important?
Age is the biggest risk factor for almost all chronic disease and death. However, the unique biology of aging can be very different in people who share the same birth year. That is why we see some individuals in their 70s who look 50 years of age, and vice versa; highlighting the need for a better way to measure bodily aging. This is why the concept of biological age was created.
In the OMICm Age publication, we document just how important this distinction is. Chronological age simply isn’t a reflective metric of the underlying, biological differences in aging. OMICm Age was trained to do that in a much better way, as demonstrated in our death prediction models.
How was OMICm Age conceived with Harvard collaborators?
In 2020, there were only nine universally recognized, biological hallmarks of aging. By 2023, that number shot up to 14! The reason for this increase is that aging is enormously complex ,and we can see change in almost every organ and biological process as we get older.
Given the importance of quantifying the biological aging process, TruDiagnostic decided to collaborate with researchers at Harvard University to create the most robust and informative biological age measurement to date.
The complexity of the aging process makes quantifying it down to a single metric difficult. However, our approach was to measure as much variation in aging through large-scale, high-powered, multi-omic analysis. By quantifying each Omic, we believed we could uncover insight into a wide variety of hallmarks of aging and other unique biological aging processes.
This research project started in late 2020, with the creation of an aging dataset called the Massachusetts General Hospital Aging Biobank Cohort (MGH-ABC). From this dataset, we analyzed aging biomarkers in over 30,884 participants. Additionally, in a select and smaller group of 5,000 people, we did advanced metabolomic, epigenetic, and proteomic analysis.
With these additional omic measures, we were able to create the OMICm Age clock. This is a robust 2nd generation clock that shows higher associations to age-related diseases over any other previously published clock; representing an effective way to quantify biological aging through DNA methylation alone.