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Amelior Ingredients

and the science behind them

Calcium Alpha-Ketoglucarate is a special form of mineral calcium. 

We chose this ingredient due to its positive impacts on lifespan, healing, and its assistance in fighting age-related disease.

A multi-year controlled study on mice found calcium alpha-ketoglucarate “promotes longer, healthier life, associated with a decrease in levels of inflammatory cytokines. Strikingly, the reduction in frailty was more dramatic than the increase in lifespan” 

Studies on Alpha-Ketoglucarate have shown that it improves the senescence-associated phenotypes of bone marrow, and promotes healthy gene expression to slow and even reverse the cellular aging that results in osteoporosis. It increased the bone mass, and reduced age-related bone loss. It also accelerated healing of damaged bone and improved age-associated epigenetic markers. 

EGCG is found naturally in Green Tea, and is the main reason why green tea is popularized as a therapeutic drink. 

We chose this ingredient due to its proven and positive impacts on reversing and treating diseases, its powerful effect fighting cancers, and its help in regulating healthy gene expression. 

Epigallocatechin-3-gallate (EGCG) is a type of Catechin – a natural antioxidant that helps to prevent cell damage. It has been shown to offer multiple effects on human pathological and physiological processes. It offers antioxidant, anti-inflammatory, anticollagenase, and antifibrosis effects. 

Accumulating evidence demonstrates that EGCG inhibits tumor progression, and is used in clinical trials for the treatment of various types of cancer and other diseases

More interestingly in our line of work, EGCG has been found to reactivate methylation-silenced tumor suppressor genes. In other words, it helps to remove epigenetic markers and ‘wake up’ genes that naturally prevent cancer from developing in the first place. 

Sulforaphane is a natural plant compound found in cruciferous vegetables, like broccoli and brussels sprouts. It’s well-known for its antioxidant, antimicrobial, and anti-inflammatory properties. 

While it has a ton of health benefits, we chose this ingredient because of its effective support of epigenetic regulation and interdependence in the body’s fight against cancer. 

Pterostilben is a type of polyphenol created naturally within the body, but can also be found in almonds, grape leaves, and Vaccinium berries (like blueberries). 

We included this ingredient because of research showing its positive effect on lifespan, age-related disease, and health maintenance.  

Several studies have found that polyphenols like Pterostilbene and rapamyacin protect against age-related diseases like arthritis, osteoporosis, Alzheimer’s disease, and cardiovascular disease.

Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. 

Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. 

Humans naturally create Vitamin D when exposed to sunlight, but many aren’t getting enough – either because they have a harder time synthesizing it, or because they don’t get enough sun exposure for their skin to start. 

We included this ingredient because it has been found to slow biological aging and improve vital bodily functions.  

Studies have shown that Vitamin D supplementation increased telomerase activity, suggesting an anti-aging effect. A recent study found that Vitamin D supplementation may slow down Epigenetic Aging as measured by DNA methylation. 

Beyond its anti-aging effects, it also supports the function of your muscles and immune system. Vitamin D also aids calcium absorption, helping your bones and teeth stay strong.

DHEA is the most abundant steroid hormone created in the human body.

The levels of DHEA in the human body decline as they age, and numerous studies show a preventative role for DHEA on various age-related diseases, its ability to enhance the immune system, and its power to fight against diabetes, obesity, cancer, memory decline, and aging. 

Folate, Methylfolate, and Folic Acid are different forms of Vitamin B9.

Folate and Methylfolate are more immediately bioavailable.

Folate is naturally present in a wide variety of foods, including vegetables (especially dark green leafy vegetables), fruits and fruit juices, nuts, beans, peas, seafood, eggs, dairy products, meat, poultry, and grains.

Many countries have mandatory folate fortification programs, adding folic acid into enriched grain foods like bread, pasta, and rice in order to reduce the population’s risk of serious birth defects like Anecephaly and Spina bifida. 

Folates are essential to build and replicate DNA, and are highly involved in methylation, cell proliferation, and differentiation. 

One of the known associations in treatment-resistant depressed patients is lower levels of L-methylfolate. It is the only form of folate that crosses the blood–brain barrier and is immediately available for neurotransmitter synthesis.

It is also involved in key cellular activity to reduce the risk of depression, dementia, and stroke.

Recent studies have shown that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels cause aging-related disorders. 

Since NMN chemically changes into NAD+ in the body, supplementation of NMN effectively boosts the body’s available NAD+ to promote healthy cellular aging, maintain healthy DNA and many other key celluar processes. 

NMN supplementation has been found to promote anti-aging miRNA expression profiles, reversing age-related changes in vascular function in mice, and appeared to rejuvenate faltering mitochondria (the cell’s energy factories). 

Another study backed up those results in a human trial,  showing that the compound NMN improved expression of genes that are involved in muscle structure and remodeling. 
It additionally improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes.