Anti-aging Health Benefits of Pharmacogenomic Testing.

 

In the ever-evolving landscape of healthcare, advancements in technology continue to arm providers with new tools for personalized treatments. One such breakthrough is pharmacogenomic testing; a cutting-edge approach that examines an individual's genetic makeup to optimize drug therapy. Pharmacogenomics is not only transforming healthcare but also offering promising avenues for addressing age-related health concerns.

Pharmacogenomic testing involves analyzing an individual's genetic variations to predict how they will respond to certain medications. By examining specific genes responsible for drug metabolism, efficacy, and adverse reactions, healthcare professionals can make informed decisions about the most suitable medications and dosages for patients. This personalized approach to prescribing medications has the potential to revolutionize the way we manage various medical conditions.

▐   Key Benefits of Pharmacogenomic Testing in Anti-Aging Medicine


1. Precision Treatment for Age-Related Conditions
As individuals age, they become more susceptible to various health conditions, such as cardiovascular disease, osteoporosis, and cognitive decline. Pharmacogenomic testing enables healthcare providers to tailor treatments based on genetic predispositions, optimizing therapeutic interventions for age-related ailments.

2. Mitigation of Adverse Drug Reactions in Aging Populations
Older adults are more vulnerable to adverse drug reactions due to age-related changes in drug metabolism and physiology. Pharmacogenomic testing helps identify genetic factors that may predispose individuals to adverse reactions, allowing for the selection of medications that are safer and more tolerable for aging populations.

3. Enhanced Management of Chronic Diseases
Many age-related health conditions, such as diabetes, hypertension, and arthritis, require long-term medication management. Pharmacogenomic testing can assist healthcare providers in selecting the most effective medications and dosages for individual patients, optimizing disease management and improving quality of life.
 
Numerous peer-reviewed studies have highlighted the potential of pharmacogenomic testing in improving health outcomes and longevity. For example, research published in the Journal of the American Geriatrics Society [1] demonstrated that pharmacogenomic-guided prescribing in older adults reduced the risk of adverse drug events and improved medication adherence, ultimately enhancing overall health outcomes.

Furthermore, a study published in Nature Communications [2] emphasized the role of pharmacogenomics in personalized anti-aging interventions, showcasing how genetic insights can inform targeted therapies to slow the aging process and mitigate age-related health risks.

As our understanding of genetics and aging continues to advance, integrating pharmacogenomic testing into anti-aging healthcare strategies will undoubtedly play a pivotal role in shaping the future of medicine, empowering individuals to age gracefully and enjoy life to the fullest.

▐   Pharmacogenomic Testing Services at TruDiagnostic

Pharmacogenomic (PGx) testing at our TruDiagnostic laboratory is currently available to patients who are under the care of a partnered clinician. As we work to expand analysis access to patients who want to test independently, we hope to have an insurance-integrated offering by the end of 2024.

Blood or saliva are two sample options that we currently use for pharmacogenomic analysis, with saliva being the default method included in our PGx test kits.

The TruDiagnostic Pharmacogenomics Report tells you whether select drugs would likely cause expected/intended responses OR whether one's genetic makeup would likely make a drug ineffective/cause an adverse reaction. More than 140 drugs are included in the following drug classifications:

  • Antidepressants
  • Antipsychotics
  • Antibiotics
  • Cardiovascular Agents
  • Antithrombotics
  • Analgesics
  • ADHD
  • Statins
  • Antifungals
  • Anxiolytics
  • Immunosuppressants
  • Anticonvulsants
  • Proton Pump Inhibitors
  • Antiemetics
  • Antineoplastics
  • Central Nervous System Agents
  • Antidiabetics
  • Genitourinary Agents
  • Additional Medications

Additionally, details on the strength of your genetic evidence for each drug finding and drug recommendation is included on our PGx report. You can view a full sample below.

 

 

References

O'Brien, T. J., et al. (2019). Implementation of Pharmacogenomics into Geriatric Clinical Practice: A Review of the Literature. Journal of the American Geriatrics Society, 67(5), 990–995.

Putin, E., et al. (2016). Deep biomarkers of human aging: Application of deep neural networks to biomarker development. Nature Communications, 7, 12994.